Acetogens: acetyl: acetylation histone modification, P53 and tubulin.
Acetylation (or in IUPAC nomenclature ethanoylation) describes a reaction that introduces an acetyl functional group into a chemical compound. (Deacetylation is the removal of the acetyl group.)
Specifically, acetylation refers to that process of introducing an acetyl group (resulting in an acetoxy group) into a compound, to be specific, the substitution of an acetyl group for an active hydrogen atom. A reaction involving the replacement of the hydrogen atom of a hydroxyl group with an acetyl group (CH3 CO) yields a specific ester, the acetate. Acetic anhydride is commonly used as an acetylating agent reacting with free hydroxyl groups. For example, it is used in the synthesis of aspirin and heroin.
* 1 Acetylation of proteins o 1.1 N-alpha-terminal Acetylation o 1.2 Lysine Acetylation and Deacetylation
Acetylation of proteins
In biology, i.e., in living cells, acetylation occurs as a co-translational and post-translational modification of proteins, for example, histones, p53, and tubulins.
How does acetate or acetone burn? makes a golden Head? clostridium acetylbutylicum
Cellulose acetate (also known as zyl or zylonite), first prepared in 1865, is the acetate ester of cellulose. Cellulose acetate is used as a film base in photography, as a component in some adhesives, and as a frame material for eyeglasses; it is also used as a synthetic fiber and in the manufacture of cigarette filters and playing cards.
"replacement of the hydrogen atom of a hydroxyl group with an acetyl group (CH3 CO) yields a specific ester, the acetate.:"
CH3 CO is the acetyl radical................. measures between ( on light spectrum) between 490 and 660. Where did Carnicom show the measurements?
according to this it is at 532.
Article Visible Absorption Spectrum of the CH3CO Radical
The visible absorption spectrum of the acetyl radical, CH3CO, was measured between 490 and 660 nm at 298 K using cavity ring-down spectroscopy. Gas-phase CH3CO radicals were produced using several methods including: (1) 248 nm pulsed laser photolysis of acetone (CH3C(O)CH3), methyl ethyl ketone (MEK, CH3C(O)CH2CH3), and biacetyl (CH3C(O)C(O)CH3), (2) Cl + CH3C(O)H → CH3C(O) + HCl with Cl atoms produced via pulsed laser photolysis or in a discharge flow tube, and (3) OH + CH3C(O)H → CH3CO + H2O with two different pulsed laser photolysis sources of OH radicals. The CH3CO absorption spectrum was assigned on the basis of the consistency of the spectra obtained from the different CH3CO sources and agreement of the measured rate coefficients for the reaction of the absorbing species with O2 and O3 with literature values for the CH3CO + O2 + M and CH3CO + O3 reactions. The CH3CO absorption spectrum between 490 and 660 nm has a broad peak centered near 535 nm and shows no discernible structure. The absorption cross section of CH3CO at 532 nm was measured to be (1.1 ± 0.2) × 10-19 cm2 molecule-1 (base e).
Here is Carnicoms' info on the visible light in blood cells. ------------------- Analysis shows that the primary organism (or pathogen) characteristic of the "Morgellons" condition, as isolated and identified by this researcher, causes a signficant biochemical change in the nature of human blood in which it resides. The dramatic change in the character of the blood has also presented through visible observation for several years, but this change is now objectively and directly measurable through the use of spectral analysis.
This change in the general character of human blood, as it has been measured from several individiuals, is regarded as highly significant and expressive of a potential fundamental change in the human condition. The representative change in the character of the spectrum is shown immediately below:
The above shows the nature of the change and of the problem.
All matter reacts in a unique fashion to electromagnetic energy which, in this case, is visible light.
Hemoglobin, (the primary protein in human blood cells), has such a unique and characteristic spectrum over the visible light range. This expected, normal, or reference spectrum of hemoglobin is shown with the black line in the graph above1. This spectrum shows how a substance or element reacts to energy, and the locations of the peaks in the graph are where the hemoglobin absorbs the most energy in the visible range. In this case, this should be at approximately 414, 542 and 576 nanometers respectively. There are important variations to this expectation, and they pose serious problems that are to be confronted.
this radical is in the blood cells.................He def has that right, the em field in this measurement, we are at 528, why does it fluctuate so much?
the CH3CO is measured at absorbtion 1.1 at 532......... right in the ranges CC talks of.
This radical is acetate or ester...........
This is getting very interesting, my friend, we have to think in the radical movement of quantum physics. So,. has blood been quantumized? I think so. This is big...... Meaning this is controlled mater. or matter, including our blood. Hydrogen on base of dna has been substituted with acetate ester
This free radical, is it wireless? is controlled by EM. Are we absorbing a quantum energy, that is controlled matter? Are we absorbing this radical into our blood?
What is the origin of this radical CH3CO more on that. the particle of life or of the aether?
Okay then,,,,,,,brings us right down to the particle.............and it is in our foods and other places.....
Acetate esters have the general formula CH3CO2R, where R is an organyl group. The esters are the dominant forms of acetate in the marketplace. Unlike the acetate salts, acetate esters are often liquids, lipophilic, and sometimes volatile. They are popular because they have inoffensive, often sweet odors, they are inexpensive, and they are usually of low toxicity. =======
a double edged sword, my friends.............
Almost half of acetic acid production is consumed in the production of vinyl acetate, precursor to polyvinyl alcohol, which is a component of many paints. The second largest use of acetic acid is consumed in the production of cellulose acetate. In fact, "acetate" is jargon for cellulose acetate, which is used in the production of fibres or diverse products, e.g. the acetate discs used in audio record production.
Cellulose acetate can be found in many household products. Many industrial solvents are acetates, including methyl acetate, ethyl acetate, isopropyl acetate, ethylhexyl acetate. Butyl acetate is a fragrance used in food products.
Butyl acetate? The unnatural amino acid is butylphenolalanine. KAMMY<<<<<<<<<<<......................! Found in the banana.....................................
n-Butyl acetate, also known as butyl ethanoate, is an organic compound commonly used as a solvent in the production of lacquers and other products. It is also used as a synthetic fruit flavoring in foods such as candy, ice cream, cheeses, and baked goods.
Butyl acetate is found in many types of fruit, where along with other chemicals it imparts characteristic flavors. It is a colourless flammable liquid with a sweet smell of banana.
The other three isomers of butyl acetate are: isobutyl acetate, tert-butyl acetate, and sec-butyl acetate.
Butyl acetates are commonly manufactured by the Fischer esterification of a butanol isomer and acetic acid with the presence of catalytic sulfuric acid under reflux conditions.
Occurrence in nature
Apples, especially of the Red Delicious variety, are flavored in part by this chemical. The alarm pheromones emitted by the Koschevnikov gland of honey bees contain butyl acetate.
What is Feynman's sprinkler? did it work. The molecular dude? or the ghost matter dude? Condensed ghosts are black matter holes right? mmmmmm
....phenomenology of spontaneous Lorentz violation by a vector VEV and the experimental limits thereon.We find the general low-energy effective action of the Goldstones of this kind of symmetry breaking minimally coupled to gravity.
We compare this to the ghost condensate that has been proposed as a model for gravity in a Higgs phase.
We then summarize the cosmological constant problems and show that models in which a scalar field causes super-acceleration of the universe generally exhibit instabilities.
We discuss how the equation of state evolves in a universe where the dark energy is caused by the ghost condensate.
We comment on the anthropic argument for a small cosmological constant and how it is weakened if the inflaton self-coupling varies over the landscape of possible universes.
Finally, we discuss the reverse sprinkler, a problem in elementary fluid mechanics that had eluded a definitive treatment for decades.
23 a good number?///// remember we are going for the beginning particle. Higgs you say? Seems it is controlled by EM or scaler, or wireless?
Those 1,000 beacons of light, hanging out there somewhere? Cosmology crosses into earths aura? aether? With the help of one of those intermediate satellites? or the particles?
=================================Just an aside here. found this interesting about nodes and robot beacons.......
A particle filtering method for wireless sensor network localization with an aerial robot beacon
paper presents a new method for the 3D localization of an outdoor wireless sensor network (WSN) by using a single flying beacon-node on-board an autonomous helicopter, which is aware of its position thanks to a GPS device. The technique is based on particle filtering and does not require any prior information about the position of the nodes to be estimated. Its structure and stochastic nature allows a distributed computation of the position of the nodes. The paper shows how the method is very suitable for outdoor applications with robotic data-mule systems
"Lysozyme, also known as muramidase or N-acetylmuramide glycanhydrolase, are glycoside hydrolases, enzymes (EC 184.108.40.206) that damage bacterial cell walls by catalyzing hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Lysozyme is abundant in a number of secretions, such as tears, saliva, human milk, and mucus. It is also present in cytoplasmic granules of the polymorphonuclear neutrophils (PMN).
Large amounts of lysozyme can be found in egg white. C-type lysozymes are closely related to alpha-lactalbumin in sequence and structure, making them part of the same family. In humans, the lysozyme enzyme is encoded by the LYZ gene.
The enzyme functions by attacking peptidoglycans (found in the cell walls of bacteria, especially Gram-positive bacteria) and hydrolyzing the glycosidic bond that connects N-acetylmuramic acid with the fourth carbon atom of N-acetylglucosamine. It does this by binding to the peptidoglycan molecule in the binding site within the prominent cleft between its two domains. This causes the substrate molecule to adopt a strained conformation similar to that of the transition state. According to Phillips-Mechanism, the lysozyme binds to a hexasaccharide. The lysozyme then distorts the fourth sugar in hexasaccharide (the D ring) into a half-chair conformation. In this stressed state, the glycosidic bond is easily broken.
The amino acid side-chains glutamic acid 35 (Glu35) and aspartate 52 (Asp52) have been found to be critical to the activity of this enzyme. Glu35 acts as a proton donor to the glycosidic bond, cleaving the C-O bond in the substrate, whereas Asp52 acts as a nucleophile to generate a glycosyl enzyme intermediate. The glycosyl enzyme intermediate then reacts with a water molecule, to give the product of hydrolysis and leaving the enzyme unchanged.
Role in disease
Lysozyme is part of the innate immune system. Reduced lysozyme levels have been associated with bronchopulmonary dysplasia in newborns. Children fed infant formula lacking lysozyme in their diet have three times the rate of diarrheal disease. Since lysozyme is a natural form of protection from gram positive pathogens like Bacillus, Staphylococcus and Streptococcus, a deficiency due to infant formula feeding can lead to increased incidence of disease. Whereas the skin is a protective barrier due to its dryness and acidity, the conjunctiva (membrane covering the eye) is, instead, protected by secreted enzymes, mainly lysozyme and defensin."
"It is also present in cytoplasmic granules of the polymorphonuclear neutrophils (PMN)."
"Neutrophil granulocytes are generally referred to as either neutrophils or polymorphonuclear neutrophils (or PMNs), and are subdivided into segmented neutrophils (or segs) and banded neutrophils (or bands). Neutrophils are the most abundant type of white blood cells in mammals and form an essential part of the innate immune system. They form part of the polymorphonuclear cell family (PMNs) together with basophils and eosinophils.
Neutrophils have three strategies for directly attacking micro-organisms: phagocytosis (ingestion), release of soluble anti-microbials (including granule proteins) and generation of neutrophil extracellular traps (NETs).
The consumption of oxygen during the generation of reactive oxygen species has been termed the "respiratory burst", although unrelated to respiration or energy production.
The respiratory burst involves the activation of the enzyme NADPH oxidase, which produces large quantities of superoxide, a reactive oxygen species. Superoxide dismutates, spontaneously or through catalysis via enzymes known as superoxide dismutases (Cu/ZnSOD and MnSOD), to hydrogen peroxide, which is then converted to hypochlorous acid HClO, by the green heme enzyme myeloperoxidase. It is thought that the bactericidal properties of HClO are enough to kill bacteria phagocytosed by the neutrophil, but this may instead be step necessary for the activation of proteases."
"Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder:149. FMF is an autoinflammatory disease caused by mutations in MEFV, a gene which encodes a 781–amino acid protein denoted pyrin."
NADPH oxidase (we see over and over...)
"Neutrophils have three strategies for directly attacking micro-organisms: phagocytosis (ingestion), release of soluble anti-microbials (including granule proteins) and generation of neutrophil extracellular traps (NETs)."
**Ingestion of- don't know?... but release of granules and NETs - 'Morg-like', have our neutrophils been modified?
"NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.
Signaling in apoptosis and inflammation is often mediated by proteins of the death domain superfamily in the Fas/FADD/Caspase-8 or the Apaf-1/Caspase-9 pathways. This superfamily currently comprises the death domain (DD), death effector domain (DED), caspase recruitment domain (CARD), and pyrin domain (PYD) subfamilies. The PYD subfamily is most abundant, but three-dimensional structures are only available for the subfamilies DD, DED, and CARD, which have an antiparallel arrangement of six alpha helices as common fold. This paper presents the NMR structure of PYD of NALP1, a protein that is involved in the innate immune response and is a component of the inflammasome. The structure of NALP1 PYD differs from all other known death domain superfamily structures in that the third alpha helix is replaced by a flexibly disordered loop. This unique feature appears to relate to the molecular basis of familial Mediterranean fever (FMF), a genetic disease caused by single-point mutations."
"The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous “danger signals” as well as compounds associated with pathogens...
Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response."
Every time publisher's clearing house give me the 'search' link I have found myself focusing on inflammation and proteins. currently on inflammation,
I swear, when I win $5,000 per week for life I will totally treat you all.
What connects inflammation, hormones and proteins?
If we wipe out inflammation, can we wipe out all disease?
Me thinks so. Me thinks we can wipe out inflammation if we wipe out sugar in our systems.
Hey, BTW, they just found out that HFCS (high fructose corn surup for the clueless who are just reading) has mercury in it.
Hey, and guess what else? They found out that vaccines have been using aborted fetal cells in their makeup. Can you imagine, at the very least, someone who has to have a mandatory vaccine and is opposed to abortion?
It just gets better and better.
But we will make a difference.
We WILL come out in numbers and RULE!!! FOR THE GOOD OF THE PEOPLE.
It will backfire on them.
The meek shall inherit the earth. If a quote lasts that long, you gotta know it will last forever (or as long as necessary)
Lysozymes are from wild hen egg whites, the slimy part.
Moses, the quails, eggs, and the manna..........they were to pick up the manna and put in pots. Was the manna the quail eggs, or the resin from their poop after eating seeds? haha...........therein might be worms too. they were under the dew?......... honeydew?
lysozymes; the liposomes...................Incoporating lysozymes(from eggmembrane) into lipsomes
To define a model for enzyme latency in vitro, the capture was studied of egg white lysozyme by liposomes (phospho- ipid spherules in the smectic mesophase). Gel filtration resolved liposomes formed in the absence of enzyme from
Basically, lipsomes were created from lysozymes, the membrane protein..........
detergent (1,2). Insight has been obtained into the action upon biomembranes of steroids, polyenes, toxins, etc., by the use of suspensions of lysosomes, mitochondria, etc. (1, 2, 20). Kinetic studies of the release of enzymes from these are complicated by absence of data on structure of the enzymes or the membranes which limit them from their substrate. Now that it is possible to form model liposomes with lysozyme captured therein, the model system can be extended by capturing enzymes whose substrates can be determined in the presence of liposomes.
endogenous "danger signals" in the inflammasome............
NMR structure of PYD of NALP1, a protein that is involved in the innate immune response and is a component of the inflammasome. The structure of NALP1 PYD differs from all other known death domain superfamily structures in that the third alpha helix is replaced by a flexibly disordered loop. This unique feature appears to relate to the molecular basis of familial Mediterranean fever (FMF), a genetic disease caused by single-point mutations."
that medit. fever is associated with the membrane protein..........in Influen A...........as well.
skyship: those wormlike strands that make microtubules?
Jul 18, 2013 0:56:59 GMT -5
MK_Alberta: mpatability to D. discoideum for subcutaneous transmi
Jul 19, 2013 6:46:49 GMT -5
skyship: MK Alberta: I think you might have something, there, we looked at that long time ago, but, I think we did not think that it could be use actually in the human body. We thought it was used as a homologous thing meaning like cells, microtubules.
Jul 24, 2013 0:32:58 GMT -5
skyship: how come you can't read the threads, can you log on? Even as a guest you should be able to read what us hopeful researchers, or wanna be discoverers are doing as we morph the Morgellon Maze.
Jul 24, 2013 0:34:49 GMT -5
kritters: under "legend" are "new posts" and "no new posts". What is that about? clicking on new posts do not go to new posts.
Aug 9, 2013 9:47:15 GMT -5
XDelilah: I had 72 lesions this summer and was committed to a psyche ward 4x when I went to different hospitals, terrified by the biting, crawling and stinging sensations. They drugged me up and diagnoses me with 'delusional parasitosis'.
Aug 29, 2013 8:23:24 GMT -5
DonMae: I'm not seeing the pics.
Sept 14, 2013 13:09:29 GMT -5
aqt: how sickening XDeliliah.. I am truly sorry for your suffering as I can relate all too well. May you find peace.
Sept 16, 2013 15:09:15 GMT -5
kansas: Hello to all of you suffering from Morgellons I had the worst of it (hopefully) for a year and a half!
Oct 2, 2013 21:57:30 GMT -5
kansas: I just found this site and wanted to share what has finally stopped the horrific itching for me. It's seems that MSM and daily vitamin c, taken daily is helping. i have not idea why? i also think a dehumidifier and a uv air cleaner was used around the same
Oct 2, 2013 22:03:43 GMT -5
kansas: This is huge. A infectious disease doc on a plane with my best friend said this is bacterial. Really?! Not in our heads!
Oct 2, 2013 22:07:29 GMT -5
kansas: One more thing before I go, I sort of think this bacteria lives in our mouths. I have be using a germ killing mouthwash for the tooth pain and think it is helping the fight.
Oct 2, 2013 22:13:51 GMT -5
kansas: what is also terrible about this Morgellons is the predatory salesmen on the net and doctors pretending this is imaginary when we need medical help!
Oct 2, 2013 22:20:13 GMT -5
chelliebelle2468: does anyone know anything about the conditions and diseases associated from HLA-B27?
Oct 15, 2013 14:52:27 GMT -5